Posted by ixus on May 1, 2005, at 4:02:47
In reply to Re: why do antipsychotics have anti-depressant eff, posted by mogger on May 1, 2005, at 3:27:59
> thanks chemist,
> you sound brilliant. why do you think antipsychotics like seroquel have anti-depressant effects on Unipolar depressives (always low)?
> moggerHi Mogger,
they can be of help because they antagonize 5-HT2A and 5-HT2C.
At higher dose you target more dopamine receptors which is not helpful in unipolar depression/anxiety.
There is also another hipothesis i.e. at lose dose you bind dopamine autoreceptors/presynaptic (they provide feedback for the releaser) thus increase dopamine release. At higher dose you targer also postsynaptic dopamine receptors - shut down dopamine transmission.
/ixus
poster:ixus
thread:491782
URL: http://www.dr-bob.org/babble/20050428/msgs/492201.html