Posted by ed_uk on March 5, 2005, at 14:27:21
Hi,
Some people on p-babble have found that reboxetine made them more depressed. Perhaps reboxetine has a therapeutic window. Nortriptyline is believed to have a therapeutic window and nort is thought to act mainly as an NE reuptake inhibitor. Perhaps reboxetine would work better at much lower doses than those which are are commonly used.
Anyone care to comment? Former reboxetine users? Current rebox users?
Also, maybe reboxetine is affecting one or more receptors that we don't know about yet........
OR.... maybe other NE reuptake inhibitors are better tolerated because of the other receptors that they effect eg. ACh, 5-HT2, H1, alpha-1 etc. Alpha-1 antagonism may reduce genito-urinary side effects, 5-HT2 antagonism may enhance AD efficacy.
OR.... maybe the worsened depression was just a horrible coincidence.........
Ed.
poster:ed_uk
thread:467005
URL: http://www.dr-bob.org/babble/20050304/msgs/467005.html