Posted by Larry Hoover on March 5, 2005, at 9:48:46
In reply to Re: Codeine produced the opposite effect!!! » Larry Hoover, posted by ed_uk on March 4, 2005, at 10:47:27
> In fact, I think it is quite possible that extensive metabolisers are among the few people who *do* get a substantial analgesic effect from codeine at standard analgesic doses (30-60mg).
>
> Unfortunately, most people do not seem to get a good analgesic effect from standard doses of codeine (on its own). In many cases, it is significantly less effective than other analgesics such as paracetamol (acetaminophen). Combining 60mg of codeine with 1000mg of paracetamol seems to be a useful combination though.
>
> See codeine 60mg at the bottom of the analgesic 'league table'.
>
> http://www.jr2.ox.ac.uk/bandolier/booth/painpag/Acutrev/Analgesics/lftab.html
>
> Codeine 60mg NNT 16.7
>
> Ed.Nice table.
Given this data, it seems absurd how often e.g. Tylenol 3 (30 mg codeine, 325 acetominophen/paracetamol) is prescribed for pain.
I had a shoulder surgery some years back, which involved a hammer, chisel, grinder, saw, and drill. They sent me home with T3's. Ya, right.
Lar
poster:Larry Hoover
thread:466068
URL: http://www.dr-bob.org/babble/20050304/msgs/466907.html