Posted by ed_uk on March 4, 2005, at 10:47:27
In reply to Re: Codeine produced the opposite effect!!! » NARCOLEPTIC, posted by Larry Hoover on March 4, 2005, at 10:32:19
In fact, I think it is quite possible that extensive metabolisers are among the few people who *do* get a substantial analgesic effect from codeine at standard analgesic doses (30-60mg).
Unfortunately, most people do not seem to get a good analgesic effect from standard doses of codeine (on its own). In many cases, it is significantly less effective than other analgesics such as paracetamol (acetaminophen). Combining 60mg of codeine with 1000mg of paracetamol seems to be a useful combination though.
See codeine 60mg at the bottom of the analgesic 'league table'.
http://www.jr2.ox.ac.uk/bandolier/booth/painpag/Acutrev/Analgesics/lftab.html
Codeine 60mg NNT 16.7
Ed.
poster:ed_uk
thread:466068
URL: http://www.dr-bob.org/babble/20050304/msgs/466433.html