Posted by linkadge on February 25, 2005, at 15:50:58
In reply to Re: 5-HT2C receptor antagonists, posted by banga on February 25, 2005, at 0:39:59
It's kind of a mixed bag. I read in a few places that there was a little paradox. Atypicals increase dopamine release in the frontal cortex via 5-ht2a angatonism, yet most of them bind fairly strongly to d2 receptors in the frontal cortex which can lead to some negation of their effect.
Yes, prozac dirtier than the other SSRI's. One of its interesting effects is that it acts as a 5-ht2c antagonist. Prozac leads to more dopamine in the frontal cortex than the other SSRI's.But, I would imagine that by taking prozac there would be an overall *agonism* at the 5-ht2c receptors. Ie it would only block a *certain portion* of the serotonin that it increases.
So I would imagine that this article is talking about blocking futher blocking the 5-ht2c receptor which seems to block the AD effect of the drug.
Linkadge
poster:linkadge
thread:462559
URL: http://www.dr-bob.org/babble/20050222/msgs/463263.html