Posted by linkadge on February 24, 2005, at 15:23:50
In reply to Re: 5-HT2C receptor antagonists » Optimist, posted by KaraS on February 24, 2005, at 14:43:29
Both 5-ht2a and 5-ht2c "agonism" causes reduced dopamine in the prefrontal cortex.
5-ht2a/c anatagonists can reduce this effect and increase prefrontal dopamine release.
5-ht2a agonism can cause anxiety and insomnia, and 5-ht2c agonism generally causes sexual dysfunction and decreased apetite.
However. Blocking the 5-ht2c receptor blocks the antidepressant effect of prozac. See the link...http://biopsychiatry.com/5ht2cantid.htm
So 5-ht2c antagonism might reduce the AD effect of a drug.
There is a lot over overlap between the 5-ht2a/c receptors and their clinical actions.
Linkadge
poster:linkadge
thread:462559
URL: http://www.dr-bob.org/babble/20050222/msgs/462796.html