Posted by banga on January 3, 2005, at 2:03:11
In reply to TCAs and Weight Gain, posted by tygereyes on January 3, 2005, at 0:35:43
Funny you should ask, I was just discussing this with someone here a few threads ago.
Ed gave this reference:
You might be interested in this.......J Clin Psychiatry. 1987 Jan;48(1):27-8.
The effect of desipramine on body weight in depression.
Levitt AJ, Joffe RT, Esche I, Sherret D.
Twenty-six patients with major depressive disorder were treated with desipramine for 4 weeks to determine the effect of the drug on body weight. Responders to desipramine showed a weight gain only at Weeks 3 and 4; nonresponders had a nonsignificant loss of weight. The increase in body weight of the responders was independent of dosage, sex, and hospitalization status. These findings suggest that the small increase in body weight that occurs in patients taking desipramine is associated with treatment response.
In addition, desipramine may be a valuable treatment alternative for those patients in whom excessive weight gain is undesirable.
It sounds as though desipramine has much less effect on weight than say clomipramine. I too am trying to find a TCA--pro-norepinephrine type--that does not lead to much weight gain. I will probably try desipramine next.
It must be difficult to balance the stress caused by your eating disorder tendencies and finding medications that won't stress you out even more at this early stage. Perhaps desipramine could offer help for you. Best of luck to you.
poster:banga
thread:437085
URL: http://www.dr-bob.org/babble/20041228/msgs/437110.html