Posted by raybakes on December 15, 2004, at 9:18:07
In reply to Re: SSRI/dopamine antagonism, posted by Mistermindmasta on December 15, 2004, at 1:11:38
Similarly, I hypothesize that when a certain percentage of SERT are blocked, the DAT actually begins to reuptake serotonin to make up for less SERT activity. That's probably a stretch since NE and DA are much more chemically similar than 5-HT and DA. But who knows...
Yes, this abstract from earlier in the thread agrees with what you say...
"The results demonstrated the inhibition of SERT by SSRI in human in vivo during the chronic treatment and, unexpectedly, an elevation of DAT. This apparent SSRI-induced modulation of the dopamine system may be associated with the side effects of these agents, including sexual dysfunction."
Ray
poster:raybakes
thread:428740
URL: http://www.dr-bob.org/babble/20041211/msgs/429826.html