Posted by ed_uk on December 1, 2004, at 11:02:24
In reply to Depersonalization and Depression (Meds?), posted by cache-monkey on December 1, 2004, at 10:50:13
Hello,
Perhaps naltrexone might be useful. It is an opioid antagonist which is taken by mouth. I am suggesting naltrexone because of a little study which looked at the effect of naloxone (another opioid antagonist) on depersonalisation. Naloxone is given by injection, which is why I wondered whether naltrexone might be useful.
J Psychopharmacol. 2001 Jun;15(2):93-5.
Effect of naloxone therapy on depersonalization: a pilot study.Nuller YL, Morozova MG, Kushnir ON, Hamper N.
Bekhterev Psychoneurological Research Institute, St-Petersburg, Russia. nuller@J3971.spb.edu
To test the hypothesis of the role for the opioid system in the pathogenesis of depersonalization, the effect of naloxone (an opioid receptor blocker) on the symptoms and corticosteroids secretion was studied in patients with depersonalization syndrome. Fourteen depersonalization patients were treated with naloxone: 11 patients received single doses (1.6 or 4 mg i.v.) and three others received multiple infusions, with the maximal dosage being 10 mg, and the effect of naloxone on symptom severity was determined. In eight patients, the cortisol, cortisone and corticosterone content in the blood plasma was determined prior to and after the 4 mg naloxone infusion. A reversed-phase microcolumn high-performance liquid chromatography with ultraviolet detection was applied for assessment of glucocorticoids. In three of 14 patients, depersonalization symptoms disappeared entirely and seven patients showed a marked improvement. The therapeutic effect of naloxone provides evidence for the role of the endogenous opioid system in the pathogenesis of depersonalization.
Regards,
Ed.
poster:ed_uk
thread:422808
URL: http://www.dr-bob.org/babble/20041201/msgs/422817.html