Posted by King Vultan on November 23, 2004, at 12:37:39
In reply to I just don't get it! Need advise please, posted by denise1904 on November 23, 2004, at 10:23:58
> Hi,
>
> Can somebody offer some possible opinions. About 8 years ago I was taking 20mg of Seroxat (Paxil) daily and getting a really robust response. I decided to give it a try without antidepressants and about 4 years ago started feeling unwell again. I tried going back on Seroxat along with many other antidepressants and I felt just as bad if not worse.
>
> Anyway two years ago the psychiatrist decided to put me back on Seroxat only this time at a higher dose and they are working but not half as well, I feel tired alot of the time but am extremely grateful I'm not as bad as I was.
>
> I just don't understand why they don't work like they used to anymore, as it wasn't even as though I had developed a tolerance to them before I came off them. I actually came off them partly so as not to develope a tolerance to them.
>
> I've had my thyroid and T3 levels checked (their ok), I've tried rTMS hoping this would make the Seroxat work like it used to, I don't drink any more than I used to (which is very little), nothing majorly bad has happened to me this time round, so I just don't get it.
>
> I'm trying to think about this logically, and all I can think is that it could be one of the following reasons, Can somebody let me know what they think?
>
> 1) I've got less serotgenic neurons than I used to have, so am not making as much.
>
> 2) Tryptophan or whatever makes Serotonin is not crossing my blood brain barrior as well as it used to.
>
> 3) There is a problem with my serotonin transporter sites.
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> 4) I've now got too many Serotonin post synaptic receptors.
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> Any other ideas?
>
> I realise that I'm probably over-simplifying things and I know it's just not that simple (how I wish it was).
>
>
> Can somebody advise please on what the other possibilities could be?
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>
>
> Thanks.......Denise
>
>
It could just as easily be some kind of issue with norepinephrine or dopamine. These two systems are important components of one's overall mood and are not well served by SSRIs. There is a school of thought that people tend to have better long term success using a drug that works on both serotonin and norepinephrine. I suppose that would be my belief also.Todd
poster:King Vultan
thread:419276
URL: http://www.dr-bob.org/babble/20041123/msgs/419342.html