Posted by jasmineneroli on November 23, 2004, at 0:49:24
In reply to Re: How do I know IF I am a slow metabolizer? » jasmineneroli, posted by Larry Hoover on November 22, 2004, at 7:36:30
Hey Lar!
EXTREMELY cool link! I think I've found a new obsession! (J/K)
Well, I think I've discovered the reason why I'm a slow metabolizer of 2C19........oral contraceptive pill use for 5 years in the mid 1970's! (And subsequent contraceptive use in an attempt to mitigate peri-menopause symptoms).Since they inhibit 2C19, do you think it's possible that inhibition of an enzyme for a long period of time by a certain drug or group of drugs (particularly the "old" high dose Oral Contraceptives) permanently effects the enzymes' abiilty to metabolize efficiently, or at all? I did notice that a couple of notes on other isoenzymes on the table, stating "irreverseable effect".
I think this theory may well apply to me. It's also interesting to note that I didn't develop any irritable depression until I took O.C.'s ( always had anxiety, tho'). So much so, that I was really hesitant to take them again to help perimenopause. After that experiment with them, and horrible suicidal depression/anxiety, even my GP of the time said " I think I've made you sick, by putting you back on the pill"!
There has to be a connection between it all.
For some reason, I'm finding this unravelling process, very therapeutic. I feel like I'm finding answers to "why am I like this?" and "why do I keep responding so badly with the same S/E's?". It's kinda empowering. I just don't want to keep on trying drug after drug and having the same ill-effects. At least I will know which ones I definitely shouldn't try.
Thanks so very much Larry :).
Warm wishes, Jas
PS
Still working on the tryptophan plan.
poster:jasmineneroli
thread:417092
URL: http://www.dr-bob.org/babble/20041118/msgs/419195.html