Posted by SLS on November 8, 2004, at 23:28:19
In reply to Re: a1 antagonism + tranylcypromine » SLS, posted by Iansf on November 8, 2004, at 10:50:17
> > > The degree of MAO inhibition is relevant, but past a certain dose it is probably irrelevant.
> >
> > I read an abstract years ago that postulated high-dosage Parnate resulted in the downregulation of 5-HT2 receptors. Low-dosage did not.
> >
> >
> > - Scott
>
> What is the significance of that?
>
> John Mc
I would have to research the matter further to better understand it all, but it is known that several antidepressants (nefazodone, mirtazapine) and the atypical neuroleptics (which have antidepressant properties) block 5-HT2a receptors. 5-HT2 blockade or the downregulation of these receptors in the absence of reuptake inhibition might produce similar results. I don't know.
- Scott
poster:SLS
thread:400754
URL: http://www.dr-bob.org/babble/20041108/msgs/413569.html