Posted by Chairman_MAO on November 4, 2004, at 4:10:07
In reply to Re: Downregulating dopamine autoreceptors, posted by King Vultan on October 17, 2004, at 0:15:35
For what any anecdote is worth:
I used to take trazodone to sleep on Parnate. I absolutely hated it, primarily because of its adrenergic antagonism. I found it negated a good part of the motivational and anti-ADD effects of the Parnate that are essential for me.
At any rate, once I got over 150mg/day, the insomnia paradoxically disappeared, and I sleep like a baby. Jay Amsterdam's study of tranylcypromine in treatment-resistant depression is right on the money. At 200mg/day, I find Parnate profoundly calming, not activating. The insomnia is gone--although I can choose to stay up, as I did tonight, but that's a sleep hygene issue of mine that should not be band-aided with drugs--as is any agitation. The improvement in depression compared to, let's say, when I was taking 80mg/day is minimal, but the improvement in social phobia and self-esteem is INCREDIBLE and worlds beyond 80mg/day. Also, the hypersexuality of the lower (10-30mg/day) doses and the occasional anaorgasmia of 80mg/day seem averaged together to create a healthy, moderate sex drive with AMAZING orgasms and erotic sensorium.
I am convinced that the reason everyone thinks Nardil is better than Parnate for social phobia is that the doses of Parnate used are woefully inadequate. Honestly, I could not conceive of anyone needing any adjunctive medication for social phobia at 200mg/day, but if they did, I'm sure a pinch of clonazepam, beta-phenyl-GABA/baclofen, Neurontin, or your MAOI-friendly treatment of choice would fill in any gaps. I personally find that picamilon works wonders with it, although if there were a safe GABA-T inhibitor on the market, I'd definitely try that to push things more toward the Nardil end of things.
Maybe I should try a high quality valerian extract; anyone know of anything else besides Depakote, gama-vinyl-gaba, and the hydrazine MAOIs that inhibits GABA-T?
Best to all,
--cm
poster:Chairman_MAO
thread:400754
URL: http://www.dr-bob.org/babble/20041103/msgs/411447.html