Posted by linkadge on November 4, 2004, at 11:11:19
In reply to Re: Classical Neuroleptics: Dysphoria in pill for » linkadge, posted by jboud24 on November 4, 2004, at 9:47:15
I think we are agreeing in most sences.
There is only one thing. 5ht2a receptor activation *can* be actually anxiolitic in some sences. Activation of the 5-ht2a receptor can cause psyical anxity by increasing cortisol release, but that sence of enlightenment can in reality pull pull people out of their daily lives. Ie the antiobsessive qualities of ssris are presumably due to 5-ht2a/c receptor activation.
Just as 5-ht2a/c activation can help someone *pull out* (making the world seem surreal), its blocade can exasperate OCD thoughts and make things seem *super real*.
Some people attribute some of the SSRI's effect
to the general lowering of dopamine caused by 2a/c receptor activation.Another thing, is that blocade of the 5-ht2a receptors can impair short term memory,
see www.nootropics.com
Whenever I add periactin (a potent 2a/c) blocker to citalopram for sleep, it helps sleep but the next day I feel paniky, confused, and a little blue. I have heard this from others as well. It helps the psysical anxiety, but can actually be anxiogenic in the sence that it can promote thought frenzied hypercholinergic states.
Anyhow the point I am getting to is this. 2a/c receptor activation/blocade can have varying effects on anxiety dependant on the state that the individual is in.
Linkadge
poster:linkadge
thread:411009
URL: http://www.dr-bob.org/babble/20041103/msgs/411641.html