Posted by Chairman_MAO on November 4, 2004, at 4:29:03
In reply to Re: Classical Neuroleptics: Dysphoria in pill form!, posted by linkadge on November 3, 2004, at 14:00:58
Atypicals are less likely to cause TD primarily because they aren't nearly as potent DA blockers as the typicals in the doses usually prescribed of each. Also, there is something beyond my understanding called the "dissociation constant" that comes into play, also. Atypicals, IIRC, do not bind as "tightly" to the receptors as the typicals do, or something like that.
I don't have any sources in front of me, but I'd be willing to bet lunch at a nice restaurant that there are at least a few typicals with some meaningful degree of 5ht2a blockade.
--cm
poster:Chairman_MAO
thread:411009
URL: http://www.dr-bob.org/babble/20041103/msgs/411452.html