Posted by jujube on October 31, 2004, at 18:45:34
In reply to Re: Anybody else experience this? » jujube, posted by karaS on October 31, 2004, at 18:37:56
> > > > Thanks. I think, at this point, I am leaning that way. Perhaps after now having been on three other ADs, the Paxil may work. I am so afraid of the side effect profile of TCAs, but I will not discard them as an option. My depression this time is a bit different than previously 8 years ago, at which time I experienced what was more of an anxious depression - high on anxiety and panic. In the past few months, I am experiencing a more andhedonic depression with anxiety. The anhedonia is pretty scary. Oh well, I have to continue to have faith that things will get better, and that this too shall pass.
> > > >
> > > > Tamara
> > > >
> > > >
> > > > > I would think that trying the Paxil at higher dosages would certainly worth a shot, given it's positive history for you...
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> > > >
> > >
> > > Tamara,
> > >
> > > I don't think that the SSRIs tend to be very good for anergic type depressions. They may have a depressive effect on dopamine. I think that serotonin and dopamine work like a see saw with one of them on each side. If increasing Paxil doesn't work for you, then I think you are wise to look at other options. If I were you I'd look into medications that target norepineprhine and/or dopamine. Have you ever considered Wellbutrin? I'm sure that Sad Panda and some of the others here who know a lot about the TCAs will give you more information on them. Targeting dopamine alone is more complicated and probably not your next step.
> > >
> > > Kara
> >
> > Thanks Kara. I would love it if the Paxil would work again, but I am thinking that this second depression is a different beast than the first. Since I have bad anxiety which can lead to agoraphobia at times, I am a little nervous about Wellburtrin. I have heard that many people experience increased anxiety while on it. But it is an option to discuss with the pdoc. Maybe a TCA is the way to go. I'm just so scared of all the side effects, particularly the fatigue since I am so tired all the time already. Well, there has to be something out there that will help me. I am just hoping that my next drug trial will be the one that helps so that I can start doing all the things that have kept me depression-free in the past - exercising, socializing and having the energy to make a decent meal.
> >
> > Thanks again, and take care.
> >
> > Tamara
>
>
> I'm in a similar situation trying to find something that will work and that I'll be able to tolerate. Come to think of it, almost everyone on this board is in that same situation. The fact that you were able to find something that worked for you for so many years bodes well for you. Hopefully we'll all find something(s) sooner or later! I'll keep my fingers crossed for you.
>
> Kara
>
> Thanks Kara. What's frustrating for me is that I responded so well to my first AD when I experienced depression 8 years ago. But, then again, I was younger, and maybe hormonal changes effect how women respond to ADs (who know?). Anyways, I know that, with the help of the pdoc, I will find something that will work (I have to keep telling myself that). I will keep my fingers crossed for you too as well as for the others on the board who are in a similar situation.Enjoy the rest of your evening.
Tamara
>
poster:jujube
thread:409656
URL: http://www.dr-bob.org/babble/20041029/msgs/409748.html