Posted by jujube on October 31, 2004, at 17:03:55
In reply to Re: Anybody else experience this? » jujube, posted by karaS on October 31, 2004, at 16:50:33
> > Thanks. I think, at this point, I am leaning that way. Perhaps after now having been on three other ADs, the Paxil may work. I am so afraid of the side effect profile of TCAs, but I will not discard them as an option. My depression this time is a bit different than previously 8 years ago, at which time I experienced what was more of an anxious depression - high on anxiety and panic. In the past few months, I am experiencing a more andhedonic depression with anxiety. The anhedonia is pretty scary. Oh well, I have to continue to have faith that things will get better, and that this too shall pass.
> >
> > Tamara
> >
> >
> > > I would think that trying the Paxil at higher dosages would certainly worth a shot, given it's positive history for you...
> >
> >
>
> Tamara,
>
> I don't think that the SSRIs tend to be very good for anergic type depressions. They may have a depressive effect on dopamine. I think that serotonin and dopamine work like a see saw with one of them on each side. If increasing Paxil doesn't work for you, then I think you are wise to look at other options. If I were you I'd look into medications that target norepineprhine and/or dopamine. Have you ever considered Wellbutrin? I'm sure that Sad Panda and some of the others here who know a lot about the TCAs will give you more information on them. Targeting dopamine alone is more complicated and probably not your next step.
>
> KaraThanks Kara. I would love it if the Paxil would work again, but I am thinking that this second depression is a different beast than the first. Since I have bad anxiety which can lead to agoraphobia at times, I am a little nervous about Wellburtrin. I have heard that many people experience increased anxiety while on it. But it is an option to discuss with the pdoc. Maybe a TCA is the way to go. I'm just so scared of all the side effects, particularly the fatigue since I am so tired all the time already. Well, there has to be something out there that will help me. I am just hoping that my next drug trial will be the one that helps so that I can start doing all the things that have kept me depression-free in the past - exercising, socializing and having the energy to make a decent meal.
Thanks again, and take care.
Tamara
poster:jujube
thread:409656
URL: http://www.dr-bob.org/babble/20041029/msgs/409709.html