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Re: MAOIs decrease density of DA receptors- KaraS » King Vultan

Posted by Larry Hoover on October 24, 2004, at 11:12:52

In reply to Re: MAOIs decrease density of DA receptors- KaraS » Kristel, posted by King Vultan on October 24, 2004, at 10:28:13

> Be that as it may, the abstract is interesting, but I don't know enough about dopamine receptors to come to any firm conclusions myself. I was aware that phenylethylamine is a classic MAO-B substrate, which is one of the reasons behind chocolate appearing on some of the "Do not eat" lists for MAOI patients (PEA has been called the "chocolate amphetamine"). Inhibiting MAO-B as do the older MAOIs--and as selegiline does, as well--does increase PEA levels, and there appears to be at least a possibility that there may be some therapeutic benefits from this.
>
> Todd

I'd like to lend support to the idea that MAO-B inhibition has therapeutic benefits. I'm currently experimenting with low-dose oral selegiline, and I'm finding that my optimal intake might lie at only 7.5 mg/day....still tweaking though. I also find that oral DLPA potentiates the effect considerably, lending credence to the PEA mechanism.

My cognitive function continues to improve, on a day to day basis. I believe that my physical endurance might be increasing, but more slowly. I don't wish to place expectations on myself, but it seems to be the case.

I think the classical focus on the Big Three neurotransmitters is very short-sighted. Without getting too lost in semantics, perhaps PEA and taurine and GABA and phosphatidylserine and others might best be called neuromodulators....but in any case......

Lar

 

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poster:Larry Hoover thread:406550
URL: http://www.dr-bob.org/babble/20041024/msgs/406622.html