Posted by yznhymer on September 21, 2004, at 20:07:27
In reply to Re: Moclobemide/Manerix vs. Nardil, posted by King Vultan on September 21, 2004, at 12:54:50
Hi Folks...
I've been on maclobemide for a couple of years at least and my experiences pretty much mirror the description Scott provided. I experienced no side effects whatsoever. It has been easy to purchase from Canada with a doctor's prescription, but my latest pdoc was not able to get any information out of Roche Canada about the drug other than that contained in the monograph. Finding reliable information about augmenting the drug in the states is a bit problematic.
I certainly do think maclobemide is worth a trial because of the side effect cluster. It hasn't pulled me out of my chronic lethargy but I haven't had any scary suicidal I-can't-stand-the-pain periods either. Still, I'm hoping for something more. Cymbalta, Parnate, and ESAM (when available) look like my best AD options at this point.
Mark
> > Hi Everyone,
> >
> > I met with a new pdoc today who suggested that I try Manerix (a reversible MAOI) instead of Nardil. I have seen little written about Manerix in terms of its side effects and efficacy, especially with respect to anxiety.
> >
> > Does anyone out there have experience with Manerix and can compare it to Nardil?
> >
> > thanks!
> > maddog
>
> In "Clinical Advances in Monoamine Oxidase Inhibitor Therapies", there's a chart listing moclobemide side effects vs. amitriptyline and placebo. Moclobemide side effects were nearly identical to placebo in some cases, such as dry mouth and sedation, less than placebo in a couple (constipation and tachycardia), but significantly more than placebo in insomnia (~18% vs. ~2%) and gastrointestinal discomfort (~39% vs. 20%). Amitriptyline had brutal dry mouth (~96% vs. <20% on both moclobemide and placebo) and was signficantly more sedating, at about 53% versus about 16% for both placebo and moclobemide.
>
> Todd
poster:yznhymer
thread:393164
URL: http://www.dr-bob.org/babble/20040921/msgs/393477.html