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Re: Moclobemide/Manerix vs. Nardil

Posted by SLS on September 21, 2004, at 7:32:36

In reply to Moclobemide/Manerix vs. Nardil, posted by maddog on September 20, 2004, at 20:55:36

> Hi Everyone,
>
> I met with a new pdoc today who suggested that I try Manerix (a reversible MAOI) instead of Nardil. I have seen little written about Manerix in terms of its side effects and efficacy, especially with respect to anxiety.
>
> Does anyone out there have experience with Manerix and can compare it to Nardil?
>
> thanks!
> maddog


In my estimation, moclobemide is not nearly as effective for depression as Nardil. However, for most people, moclobemide is virtually without side effects. I can't comment with as much certainty as to how effective it might be for anxiety. However, it did not fair well in US clinical trials for social phobia, and failed to get approved by the FDA.

I tried moclobemide. It made my depression much worse. This is not very common, though. What is common is for one to feel better during the first week at dosages no higher than 300mg. However, the improvement most often fades, and necessitates dosage increases to as high as 900-1200mg. I think the reason you don't hear much about moclobemide is simply because it is just not consistently effective. That being said, you still might want to give it a try before moving on to the more potent drugs. Although dietary restrictions are often deemed unnecessary, still it has been recommended by some researchers that one not ingest any more than 50mg at any one meal. There have also been quite a few reports of serotonin syndrome developing with the addition of a SSRI, although there are a few doctors who claim to successfully combine the two drugs.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9860107

I hope this helps.


- Scott

 

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