Posted by SLS on September 11, 2004, at 17:16:06
In reply to glutamate inhibitors, glutamate releasers, posted by linkadge on September 11, 2004, at 15:38:44
> How is it that two, totally opposite mechanisms of a drug can provide antidepressant properties. Drugs like modafanil cause a release of glutamate and have antidepressant properties. On the other hand, drugs like riluzole reduce glutamate activity and have antidepressant properties.
>
> I'm confused
>
> Linkadge
I think it is arguable whether or not modafinil has antidepressant properties. Stimulating, yes. In any event, modafinil has been found to activate orexinergic neurons in the hypothalamus. This property might be responsible for some of its stimulant effects.
- Scott
poster:SLS
thread:389725
URL: http://www.dr-bob.org/babble/20040909/msgs/389763.html