Posted by Dave001 on August 24, 2004, at 22:19:16
In reply to dave, posted by alesta on August 24, 2004, at 20:35:19
>day is .05-2 mg, and they said they used from 10-120 mg/kg for the rats! your scaling of 10 mg to the human equivalent was bad enough. i can't imagine what the equivalent of 120 mg would be for a human!
>Maybe I was not clear in my last post. When I said 10 mg/kg fed to rats would correspond to an approximate dose of 50 mg for a 60 kg human, I meant 50 mg *total*, not 50 mg/kg.
Oops! I messed up... I meant to say mice, not rats. 10 mg/kg in mice would equal about 50 mg total for a 60 kg human; 10 mg/kg fed to rats would be about equal to 100 mg total in humans.
The message is still the same though: the *relative* dose equivalent on a mg/kg basis is higher for rodents than humans. That is, 12.3 mg/kg for a mouse is equal to 1 mg/kg in a human, which is equal to 6.2 mg/kg in rats, etc. So you can see that these rodents can tolerate much higher doses than humans based on weight.
Dave
poster:Dave001
thread:380741
URL: http://www.dr-bob.org/babble/20040821/msgs/381956.html