Posted by alesta on August 24, 2004, at 10:24:14
In reply to Re: is Ritalin neurotoxic?, posted by Shawn. T. on August 24, 2004, at 5:41:59
hello.
please look at this hyperlink:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9365033
so, great, ritalin is in the clear. but now i'm wondering about the amphetamines. does this study indicate that amphetamines are neurotoxic? or is this another study where they *injected* the rats with *super-high* doses in their brains? any help would be vastly appreciated. i feel this info could potentially help people.....
luv you,
amy> Dopamine- induced neurotoxicity is primarily a result of the oxidation of free intracellular dopamine. Ritalin prevents dopamine reuptake, an effect that has been associated with a significant reduction in dopamine neurotoxicity. Less reuptake results in less intracellular dopamine. In addition, Ritalin increases vesicular dopamine uptake; this causes an even greater decrease in free intracellular dopamine. If these arguments aren't convincing enough, see the first article below; even multiple 120mg/kg doses of Ritalin weren't enough to produce a long-term depletion of striatal DA axonal markers in mice. I think that the author of the site had good intentions; he just didn't know what he was talking about in this instance.
>
> Shawn
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9365033
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15198987
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12604695
poster:alesta
thread:380741
URL: http://www.dr-bob.org/babble/20040821/msgs/381678.html