Posted by SLS on August 24, 2004, at 7:33:21
In reply to Nardil + Nortriptyline - urgent qstns!!!, posted by ace on August 23, 2004, at 18:51:05
I experienced the beginnings of serotonin syndrome when attempting to add nortriptyline to Nardil 75mg. Symptoms included severe hypotension and altered mental status. Although not as severe as my reaction to the addition of imipramine to Nardil, it was nonetheless worrying.
I agree that it is the hyperpyrexia that is the most serious of the features of SS. I did not experience this with either TCA. I did experience muscle rigidity, though. Serious enough. However, these things resolved pretty quickly upon skipping a few doses of TCA, so you might be able to titrate nortriptyline CAUTIOUSLY to challenge your system in such a way that will allow you to abort treatment should SS appear.
Good luck. I wouldn't necessarily discourage you from attempting the combination. Just don't swallow 75mg of nortriptyline for your first dose!
- Scott
poster:SLS
thread:381471
URL: http://www.dr-bob.org/babble/20040821/msgs/381636.html