Posted by ace on August 24, 2004, at 1:34:28
In reply to Re: Nardil + Nortriptyline - urgent qstns!!! » ace, posted by Sad Panda on August 23, 2004, at 23:56:33
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> Hi Ace,
>
> 1. Do you know which P450 enzyme metabolises Nardil?Yes, but my brain is being a real bum today and wont let me remember!!
I know that Nardil inhibits it's own metabolisim & Nortriptyline uses 2D6. If there is no clash, I would leave the Nardil doseage alone. Nort is a weak SRI, I don't think this would be a problem. Hyperthermia is the deadly part of serotonin syndrome, taking a 5-HT2A antagonist counters this, so extra Zyprexa would be good as an antidote if you suspect SS, discuss it with your doctor of course. Nort is a moderate 5-HT2A antagonist too, so it's kind of self protecting.
All good advice...thanks so much, I'm printing this post out...
> 2. I don't know.
>
> 3. I just had my first Nort plasma level today. I am currently at 125mg, guess I will find out in a couple of days what my plasma level is.
>
> 4. I had transient headaches & impotence when I started it, the headaches lasted a few days, the impotence lasted a couple of weeks. Start Nort with the doseages spread a bit, but later you can take it all in one hit because it has an average half life of 36 hours, YMMW of course. Nort might lower your BP & is likely to cause you some orthostatic hypotension, but it hasn't for me. (I am obese with high blood pressure).When you say obese, how many kg are you??
It will slow your bowel down, which is good for me & one of the reasons I went for Nort instead of Rebox.
>
> Cheers,
> Panda.
Thanks so much Panda! Much appreciated as always, look after yourself...Ace
poster:ace
thread:381471
URL: http://www.dr-bob.org/babble/20040821/msgs/381600.html