Posted by chemist on August 21, 2004, at 19:35:02
In reply to Re: A question for Chemist... » chemist, posted by Shawn. T. on August 21, 2004, at 19:11:48
> The abuse potential for propoxyphene is certainly less than for drugs like morphine or hydrocodone. I would assume that the abuse potential varies among individuals to a greater degree than for more potent mu opioid receptor agonists. Where did you read that propoxyphene is a kappa receptor agonist?
**** in the Lexi-Comp's Drug Information Handbook, 12th edition, 2004-2005, Lacy et al. (editors), ISBN 1-59195-083-X (i realize this is hardly conclusive, nor are the 2 abstracts i cite):
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6151117
and
********
I believe that the drug does affect these receptors but only at concentrations that are much higher than therapeutic concentrations. For example, see http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6151117
>
> Isn't (+)-alpha-propoxyphene a synonym for propoxyphene? See http://www.cdc.gov/niosh/rtecs/el2dc6c0.html
>
> Shawn***** well, it's one synonym: others include dextropropoxyphene, alpha-d-propoxyphene, and so forth. given that analgesic activity is present in the alpha-dl- and d-diastereomers, i wanted to be really, really, clear on this. also, the PB audience is mixed, and what i call Darvon (the HCl salt of (+)-alpha-propoxyphene) might well be alien to a citizen of a nation where the same drug is sold under the name of, say, Femadol or perhaps Harmar. all the best, thanks much for the info, i do believe the drug is as you state more skewed towards to mu receptors, but there is some evidence - though scant - that kappa receptors (and even delta and sigma) get pinged.......tschuss, chemist *****
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thread:380358
URL: http://www.dr-bob.org/babble/20040821/msgs/380552.html