Posted by Ktemene on August 9, 2004, at 5:07:23
In reply to Re: Which meds increase dopamine/energy?, posted by gromit on August 8, 2004, at 4:22:10
> > You might try Selegiline, although it is a bit of a long shot. However, some people do find it very activating. One poster on this board wrote that after she took her first 10 mg dose of Selegiline she felt such a burst of energy that she went for a ten-mile run. I didn't do that, but it did stay up for 48 hours straight after my first 5 mg dose, without any ill effects. I have taken Effexor, Wellbutrin, Strattera, Provigil and Adderall but none of them has been as effective in eliminating my excessive daytime sleepiness and fatigue as Selegiline- and I only take 5 mg. At a dosage lower than 10 mg per day Selegiline is highly preferential for MAO-B, so it would certainly target your dopamine system without requiring you to go on a MAOI diet. As always, YMMV.
> >
> I've been reading alot about low dose Selegiline and I'm not clear if you can take it along with an SSRI. Assuming I can get my doc to go along with it I'd like to give it a try.
>
>Since very little MAO-A is inhibited until you get above the 10 mg dose level, there should be no problem with taking low dose Selegiline with an SSRI. There have been a couple of studies on the interaction of citalopram and fluoxetine with Selegiline, and little or no interaction was found in both studies. I have lost the fluoxetine-selegiline study link, but I will put the link to the citalopram-selegiline study here: http://www.biopsychiatry.com/citalseleg.htm
Remember that a strong antidepressant response to low dose Selegiline is uncommon. Atypical depressives with excessive daytime sleepiness and anhedonia would probably get a better response from Parnate. Once the Selegiline patch comes out, Selegiline may be the first port of call for MAOIs, but until then Parnate and Nardil are likelier candidates.
Good luck!
poster:Ktemene
thread:374543
URL: http://www.dr-bob.org/babble/20040805/msgs/375521.html