Posted by KaraS on August 5, 2004, at 2:48:21
In reply to Re: Why stay away from dopaminergics?, posted by KaraS on August 5, 2004, at 2:28:13
> > >
> > > Panda,
> > > I meant to ask you in a previous post why you prefer to stay away from dopaminergic meds? Why do you personally feel that they may be unsafe?
> > > Kara
> > >
> > >
> >
> > Hi Kara,
> >
> > Altering dopamine levels can lead to problems like Parkinsons & Psychosis. Altering 5-HT & NE doesn't seem to lead to any long term problems. The only Dopamine drugs I would use are the MAOI's. Other dopaminergics should be left to diseases that actually require it like ADD & even then ADDers seem to prefer there drugs to be skewed towards NE.
> >
> > Cheers,
> > Panda.
> >
>
> But it's the loss of dopamine neurons (not reuptake inhibition) that causes Parkinsons and it's an excessive amount of dopamine that causes psychosis, so doesn't that leave plenty of room for a therapeutic window?
>
> Also, wouldn't you include selegiline in with your safe group? It is neuroprotective in that it may help slow the process of dopamine neuronal death that occurs as we age. (Maybe you were including it when you said MAOIs?)
In addition, too much serotonin can lead to serotonin syndrome and too much NE can lead to racing heartbeat and dangerously high blood pressure. That doesn't mean that we shouldn't use meds to adjust serotonin or NE...
poster:KaraS
thread:373385
URL: http://www.dr-bob.org/babble/20040730/msgs/374249.html