Posted by chemist on August 2, 2004, at 10:46:36
In reply to Re: the no-no in grapefruit... » chemist, posted by Sad Panda on August 2, 2004, at 2:26:45
> > hello all...the compound that interferes with the metabolism of many drugs that is found in grapefruit juice is bergamottin. i actually have one manuscript on this one - sahi et al., drug metab. and disp., 30:135-140 (2001) - and they note that grapefruit juice increases the plasma conc. of drugs that are substrates of CYP3A4 (felodipine, triazolam, midazolam, terfenadine, cyclosporine, nifedipine, diazepam), CYP1A2 (caffeine), and CYP2A6 (coumarin). the lucky test subjects were beagles. it's the only m.s. i have on the topic, but anyhow, bergamottin seems to be the culprit....all the best, chemist
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> Thanks for that Chemist, have you got any info on other common interactions such as smoking?
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> Cheers,
> Panda.
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hi panda, sadly i do not have any more info at my fingertips in re: smoking other than the standard stuff you can grab from the PDR (and other refs like it) and pubmed. i cannot say that i recall smoking being flagged for anything other than decreasing plasma levels of alprazolam....it is not on my radar (being a non-smoker) but i still cannot think of smoking/drug interactions for the meds that are discussed around the table here. again, it's not something i look for, but that said, the only red flag i recall is for xanax, and i don't have an answer as to why....all that said, i'm guessing that the standard PDR/PDR-like refs make mention of it, and that maybe some other posters can chime in on this one....all the best, chemist
poster:chemist
thread:370122
URL: http://www.dr-bob.org/babble/20040730/msgs/373151.html