Posted by chemist on August 1, 2004, at 15:59:39
In reply to Re: Trazodone and Serzone combo » HappyGirl, posted by Sad Panda on August 1, 2004, at 10:52:17
hello all...the compound that interferes with the metabolism of many drugs that is found in grapefruit juice is bergamottin. i actually have one manuscript on this one - sahi et al., drug metab. and disp., 30:135-140 (2001) - and they note that grapefruit juice increases the plasma conc. of drugs that are substrates of CYP3A4 (felodipine, triazolam, midazolam, terfenadine, cyclosporine, nifedipine, diazepam), CYP1A2 (caffeine), and CYP2A6 (coumarin). the lucky test subjects were beagles. it's the only m.s. i have on the topic, but anyhow, bergamottin seems to be the culprit....all the best, chemist
poster:chemist
thread:370122
URL: http://www.dr-bob.org/babble/20040730/msgs/372917.html