Posted by chemist on July 11, 2004, at 18:38:54
In reply to Re: Parnate or Nardil is there difference?Chemist, posted by bluebird on July 11, 2004, at 17:12:25
> Hello Chemist, Are you still taking Parnate? Also what does reversible and irreversible mean when taking MAOI's? You said Marplan is a type B? I went to the site where it tells all of the meds/generics and what they are for and what chemicals they effect and so forth. Nardil - Hydrazine-MAOI/GABA transaminase inhibition, Parnate - cyclopropylamine-MAOI, Marplan - hydrazine-MAOI. So, what's the difference in them? I realize this is probably a loaded question. Still trying to learn to understand the different effects of these MAOI's. Also the atarax and klonopin don't always work at night for sleep. Benydryl seems effective. If at this point I drink black coffee with my Paxil & other meds I am out like a light. I know it sounds strange but it is a fact. Thanks for your help, bluebird
hello there, chemist here....that's a pretty lousy website if they refer to nardil and marplan both as the same chemical, and all the chemical names are wrong, don't you think? don't go back there for info, as it is likely to be incorrect. for the record: Marplan = isocarboxazid, Parnate = tranylcypromine, and Nardil = phenelzine. MAO type A inhibitors bind to the enzyme monoamineoxidase (MAO) inhibit the deamination of 5-HT, dopamine, and noradrenaline. MAO type B inhibitors bind to MAO and inhibit only the deamination of dopamine. when something binds irreversibly, it means that is pretty well stuck and can't get knocked out of the enzyme: the key is jammed in the lock, so to speak, as long as you are taking the drug. reversible inhibitors are suceptible to having their actions reversed, even while you are taking the drug. so, the MAOI-A irreversible type can be considered the most extreme: parnate is in this category. hypotension results with type A MAOIs because you stop your body's ability to remove excess noradrenaline and, if you take something that is stimulating, the effect is additive. the type B MAOIs are friendlier (they are sometimes also called selective MAOIs), and because they do not interfere with the reuptake and/or elimination of noradrenaline, are safer than the type A MAOIs from that standpoint. A and B MAOIs can be reversible or irreversible. selegiline is an irreversible type B MAOI, while lazabemide is a reversible type B MAOI. please do let me know if this clears things up, i will be happy to dig up more. as for benadryl for sleep, why not? you avoid a benzo (which can be habit-forming) and a potent anti-histamine. in my opinion, the fewer drugs, the better, and you can buy generic benadryl for much less than the brand name at any supermarket, so save yourself some money and taking 2 prescription meds! all the best, please do let us know how things progress....all the best, chemist
poster:chemist
thread:363467
URL: http://www.dr-bob.org/babble/20040710/msgs/365117.html