Posted by Aserone on July 9, 2004, at 17:36:14
In reply to The quick fixes are no fixes at all..., posted by linkadge on July 7, 2004, at 16:33:20
> Sure, opiates and stimulants may bring relief in hours but the relief is short lived and can actually worsen the course of the illness.
>
> Most antidepressants take months because it takes a while for them to trigger neurogenesis to patch up broken areas of the brain. Stimulants and opiates do not trigger neurogenesis and can generally waste what little circutry is left over.
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> Linkadge
Yes that is what the drug companies etc are trying to tell everyone but the thing is that noone knows what causes depression so everything is more or less a "quick" fix or whatever. Just because it takes a long time to work doesn't mean it's not toxic.It's all about what works for different people and just take a look around this board and try to tell me that ssri/snri's don't cause dependence. Many people have to take medication their whole life anyway so what's the difference? (Money?)
If you think the mystery of depression is solved just take a look at this for example.
"Both SSRIs and tianeptine are clinically effective; however, their opposite modes of action challenge the prevailing concepts on the need of enhancement of serotonergic neurotransmission. To better understand the differences between these two opposite pharmacological modes of action, we compared the changes induced by tianeptine and paroxetine on psychopathology, the hypothalamic-pituitary-adrenocortical (HPA) system, and cognitive functions in a double-blind, randomized, controlled trial including 44 depressed inpatients over a period of 42 days. Depressive symptomatology significantly improved in all efficacy measures, with no significant differences between tianeptine and paroxetine. There was a trend toward better response to the SSRI among women. Assessment of the HPA system showed marked hyperactivity before the beginning of treatment, which then normalized in most of the patients, without significant differences between the two antidepressants. Cognitive assessments showed no significant differences between the two drugs investigated. The results of the current study suggest that the initial effect, i.e., enhancement or decrease of 5-HT release, is only indirectly responsible for antidepressant efficacy, and they support the notion that downstream adaptations within and between nerve cells are crucial."
"This study establishes that "tianeptine enhances the presynaptic neuronal reuptake of 5-HT" leading to decreased availability of the transmitter at the postsynaptic 5-HT receptor "and thus decreases serotonergic neurotransmission," making its effect opposite to selective serotonin reuptake inhibitors (SSRIs). Since both types of medications work on depression, the authors speculate that antidepressant effects may occur "downstream," and that the usual theory of "a deficit in central synaptic neurotransmission, secondary to the deficiency in monoaminergic neurotransmission, mainly of serotonin (5-HT) and/or noradrenaline" as the cause of affective disorders, must be in error."
Opioids also regulate the HPA.
poster:Aserone
thread:362860
URL: http://www.dr-bob.org/babble/20040704/msgs/364496.html