Posted by chess on May 19, 2004, at 22:56:52
In reply to Re: Chemist...questionChemist » chess, posted by chemist on May 19, 2004, at 13:25:55
so then K becomes less potent as time goes by because it is being changed from a higher-affinity-binding nitro molecule to a lower-affinity-binding amino molecule?
> > > why is the K metabolite less potent than the parent K?
> actually, the affinity is only for the A type GABA receptor, so in any case, there is only one receptor involved....the interaction at the benzodiazepine binding site in re: the amino vs. the nitro group has to do with higher binding affinity for the parent due to direct hydrogen bonding or water-mediated hydrogen bonding with the higly diffuse and electron-rich number of lone-pairs, in contrast to the amino, which is less likely to bind as tightly. thus, it will be eliminated faster than the parent.....hope this helps, all the best, chemist
poster:chess
thread:347588
URL: http://www.dr-bob.org/babble/20040515/msgs/348749.html