Posted by chess on May 19, 2004, at 7:01:18
In reply to Re: Chemist...questionChemist » chess, posted by chemist on May 18, 2004, at 15:59:43
> you asked if K is hitting fewer GABA receptors with respect to time or if the same receptors were being hit but with lower ``strength:'' it is the latter that is closest to the correct answer. the presence of a more lipophilic derivative of K (the result of miking a nitro group into a primary amino group in the 7 position) - which is pharmacologically active - means that this metabolite will stay around in the brain longer, and i am not aware of any change in specificity for the BZD site in the GABA type A receptor.
-----that's interesting, i was expecting fewer gaba receptors being hit to have been the answer.
so then why is the K metabolite less potent than the parent K?
poster:chess
thread:347588
URL: http://www.dr-bob.org/babble/20040515/msgs/348483.html