Posted by chemist on May 10, 2004, at 22:23:47
In reply to addendem to previous post..., posted by jlbl2l on May 10, 2004, at 20:56:01
comments below.....delineated with ***, all the best, chemist
> chemist,
>
> the antacids things, i was just thinking, neurontin is effectively blocked (its absorbtion) when antacids or magnesium are present in the stomach within 2 hours approx.
>
> This presents some intersting theories.
>
**** calcium, magnesium, etc. are lewis acids, not bases. the base is what comes along in the supplement (e.g., carbonate, glutamate)****> antacids are calcium, are they not? and magnesium increases the seizure threshold while calcium effectvely lowers it. neurontin works via calcium channels. do you see what i am getting at?
>
**** magnesium and calcium in hydrated cationic form are of similar size (and exact charge, though different charge density) so they can competitively bind at each other's site...that's why either Ca^{2+} or Mg^{2+} will inhibit, but one will be a slightly better fit...*****> how could both calcium and magnesium inhibit the absorbtion of neurontin? they must compete to cross the same space in the BBB?
>
****not in the BBB: as hydrated moieties, they are subject to diffusion through the BBB, and my guess is that Mg^{2+} crosses faster due to fewer waters of hydration than Ca^{2+}....****
> If this is true, then , I dunno. I just have a lot of novel theories on many diverse diseases. What do you think about this (sorry to keep irritating you on this, but I keep coming up with some interesting ideas/points. I;m not a chemist like yourself so im sure this is easy to answer for you, but a lot of people tell me I'm going to cure diseases one day..!
>
> jlbl2l****hey, it's not irritating, it's of use for all of us......gimme some time to get the jist of this and perhaps i can provide a lucid answer....keep 'em coming!....all the best, chemist
poster:chemist
thread:345062
URL: http://www.dr-bob.org/babble/20040510/msgs/345592.html