Posted by Kon on April 26, 2004, at 11:56:36
In reply to Re: klonopin » chemist, posted by Viridis on April 26, 2004, at 1:18:47
> "klonopin is notorious for tolerance at about 6 months"
Unless I missed something in the literature, I've never come across this. In fact, in the Worthington et al. (1998)study "clonazepam alone" dose for panic disorder tended to decrease from 1.53 mg/day at 6 months to 1.22 mg/day at 12 months. The majority of patients tended to maintain same clonazepam dose or decrease dosage over time. Similar data exist for social anxiety disorder. Overall, most of the material I've come across suggests no evidence for tolerance wrt anti-anxiety effects. I'm also interested in knowing where you got the 6 month figure. Any references would be appreciated. Thanks
poster:Kon
thread:339715
URL: http://www.dr-bob.org/babble/20040423/msgs/340192.html