Posted by King Vultan on April 24, 2004, at 20:51:08
In reply to Re: anyone ever combine REMERON and MAOI???? » King Vultan, posted by SLS on April 24, 2004, at 11:48:41
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> Unless there exists a precedent for combining these two drugs, I don't think it is wise to attempt to deduce what the pharmacodynamic interactions will be by looking at a chart of receptors and pronounce it safe as if it were fact. My gut tells me that there would be no problem, but without empirical evidence demonstrating the safety of this combination, I am unwilling to give any assurances.
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> Can you offer something more definitive given the importance of the decision to be made and the consequences of guessing wrong? I look forward to seeing what you come up with, because this is a combination I would consider for myself.
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> - Scott
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>I guess I have to disagree a bit with this philosophy--if it were always the case that we were afraid to try new things, there would be no new empirical evidence. In general, the safety of other drugs with MAOIs are driven by their pharmacological profiles, and one can conclude the relative safety of a particular drug by comparing its pharmacological profile to those of drugs that are known to be either safe or unsafe. There are some exceptions to this, such as the case of Demerol, but these are few and tend to be well known.
I've posted a link to an article a couple times in the last month in regard to trazodone being used to treat MAOI insomnia; in the same section it also mentions the use of Remeron and reports that it has been used to successfully treat serotonin syndrome. I would post the link again but am home on my pathetic webtv rather than at work on my computer, and it is much more tedious doing stuff like that (though, the double quotes feature seems to work pretty well even with webtv, Dr. Bob).
Todd
poster:King Vultan
thread:339422
URL: http://www.dr-bob.org/babble/20040423/msgs/339670.html