Posted by greywolf on April 3, 2004, at 9:11:37
In reply to Re: KLONOPIN and alcohol toxic? why?, posted by snapper on April 3, 2004, at 1:20:52
If you can decipher this, maybe it will help:
"The benzodiazepine sedatives include Valium, Librium, Halcion, Xanax, Ativan, Serax, and Klonopin, to name just a few. In addition to potential effects on lipophosphate nerve membranes, these drugs work by allosterically enhancing the effect of the inhibitory neurotransmitter GABA at post-synaptic receptors. That is, they "bend" the receptor slightly so that GABA molecules attach to and activate their receptors more effectively and more often. Their chief advantage over the barbiturates, such as seconal, nembutal and phenobarbital, is that they do not act directly to open chloride ion channels, and as such are not as lethal in overdose. However, polypharmacy with alcohol and benzos is potentially fatal, as ethanol opens this channel and adds synergistically to generalized depressant effects."
poster:greywolf
thread:331902
URL: http://www.dr-bob.org/babble/20040402/msgs/332043.html