Posted by rod on March 28, 2004, at 4:35:40
In reply to Any drugs reduce cortisol?, posted by Racer on March 27, 2004, at 23:27:54
Well, a word about Tianeptine. Know the famous study with the tree shrews and their hippocampal volume? Tianeptine actually *increased* cortisol in this study:
"Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine"
http://www.pnas.org/cgi/content/full/98/22/12796"...Stress-Induced Activation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis. Psychosocial stress induced a sustained activation of the HPA axis, as indicated by the nonadapting elevation of urinary cortisol excretion in the two stress groups (Table 2). No statistical differences between the Stress and Stress + Tianeptine group were found, except on week 4 yielding significantly *higher* cortisol excretion (P < 0.02) in stressed animals treated with tianeptine. Despite the daily treatment of subordinate animals with tianeptine (Stress + Tianeptine), cortisol did not return to basal levels (Table 2). This finding is in line with one study in rats showing that stress-elicited elevations in plasma corticosterone were *not* reduced by tianeptine treatment (39). Other studies, however, demonstrated that tianeptine clearly reduces HPA response to stress (40). No effects on urinary cortisol excretion were observed in animals of the two control groups (Control; Control + Tianeptine)..."
The numbers: http://www.pnas.org/cgi/content-nw/full/98/22/12796/T2
So you can see that there are some studies which demonstate a reduction while others demonstated no effect or even an increase in cortisol.
Other drugs that really (as far as I know ;-) ) decrease cortisol are:
Imipramine
Remeron
TrimipramineI guess there are some more.
Roland
poster:rod
thread:329311
URL: http://www.dr-bob.org/babble/20040325/msgs/329357.html