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Re: Dosage of Galantamine for non Alzheimer Purpos » rod

Posted by SLS on March 6, 2004, at 7:49:25

In reply to Re: Dosage of Galantamine for non Alzheimer Purpos, posted by rod on March 6, 2004, at 5:22:00

> > Although it doesn't affect everyone this way, Ach cholinesterase inhibitors like galantamine are known to cause or make worse depression. I would still try it, though.

> Yes, I know about this and have experienced this by myself. Exelon is quite depressiogenic for me, but Galantamine schould be somewhat different, because it directly or indirectly increases stimulation of nicotinic acetylcholine receptors. Thats a feature which isnt shared with any of the other achetylcholine-esterase inhibitors.

That should boost dopamine release in PFC and NACC, right?

> I am asking because I feared the dangers of a cholinergic crisis. These drugs are lethal in overdose.

Gosh. I didn't know that.

> And hell yes, it seems to work for me! Its day 3 on 6 mg and I really feel an improvement in memory but whats most astonishing also in mood, mental energy, and improves my inability to make a decision.

That's great! What a pleasant surprise!

> I think many of these improvements are also a result of incresaed perfusion (blood flow) of the brain (Thats what the AchE Inh. also do). And conincidentally I do have left brain sided hypoperfusion,

How were you tested for this?

> Hmmm, I think I will take it for long term use.
> Other drugs I take are Lamictal, Neurontin, Solian (Amisulpride), Nortriptyline, Amantadine and Diphenhydramine.

How would you describe your illness? Maybe it has a few things in common with mine. What do you feel the amantadine is doing for you? My cocktail is similar to yours. I'm taking Lamictal, imipramine, Zoloft, memantine, and Abilify. If you continue to improve with galantamine, I'll definitely put it on my list of things to try. How do you respond to MAOIs?

> PS I hope this is not a transient effect.

I just put in a little prayer to make it so.

Good luck!


- Scott

 

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