Posted by Chairman_MAO on February 9, 2004, at 19:59:47
In reply to Re: ONLY REBOXETINE SUCCESS STORIES PLEASE!!! » Chairman_MAO, posted by ace on February 9, 2004, at 18:52:49
If you've heard good things about reboxetine and want to try it, by all means, give it a shot--sure doesn't hurt to try. If it works for OCD I will be shocked and stand corrected. I agree with you, by the way, about symptom etiologies. As much as it wishes otherwise, psychiatry usually is working with BEHAVIOR and not neurotransmitters, and the people doing the prescribing don't even see you all that often, so really almost anything goes ... that's why you should be allowed clonazepam! :(
That said, re: amisulpride, hampering the dopaminergic effect of the phenelzine may not be clinically relevant. After all, phenelzine increases dopamine levels at all synapses through MAO-B inhibition; it's not as if the antagonism of the amisulpride--at certain DA receptors, not all--would completely negate that. On the contrary, it may provide a 'stabilizing' effect. You could try it in the low dose where it acts preferentially at the autoreceptors and then increase it if you have no response.
If you ever stop taking an MAOI, I'd consider tramadol (or better opiates if you can get a script). As I'm sure you know, treating OCD without SRIs is pretty hard. Another thing you might wish to try that would be a crapshoot is adding a dopamine agonist such as pramipexole or bromocriptine. Could make it better, could make it worse.
Let me know how it goes!
poster:Chairman_MAO
thread:311129
URL: http://www.dr-bob.org/babble/20040204/msgs/311434.html