Posted by Sad Panda on February 9, 2004, at 10:12:49
In reply to Re: ONLY REBOXETINE SUCCESS STORIES PLEASE!!!, posted by linkadge on February 9, 2004, at 7:03:19
> reboxetine and nardil ??
>
> I think thats deadly
>
> LinkadgeOpinions Vary :)
From http://www.psychotropical.com/notes/622.html
"A common misconception, and one that is still repeated in supposedly authoritative texts, is that tricyclic antidepressants are unsafe if combined with MAOIs; that is only true for those that are significant serotonin reuptake inhibitors, since most TCAs are not serotonin reuptake inhibitors they are safe with MAOIs. The above comments are not intended to suggest that there is much evidence that this combination is useful. However certain properties of some 'TCAs' can be utilised to good effect when combined with MAOIs eg the potent sedative effect of a small (10-20 mg) of doxepin.
The above recapitulation helps in understanding this interesting paradox:-- that MAOIs are actually safer when combined with drugs like reboxetine that act as noradrenalin reuptake inhibitors. This is because the hypertension resulting from ingestion of tyramine (the 'cheese effect') depends on tyramine being able to enter the pre-synaptic nerve. That process is enabled by the noradrenalin reuptake mechanism and that is itself blocked by those antidepressant drugs which act through noradrenalin reuptake inhibition. ie reboxetine and TCAs."
Meanwhile, I'm still looking for someone who has taken Reboxetine to say something actually nice about it.
Cheers,
Panda.
poster:Sad Panda
thread:311129
URL: http://www.dr-bob.org/babble/20040204/msgs/311228.html