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Re: Selegiline transdermal, why not phenelzine ?

Posted by djmmm on February 2, 2004, at 16:14:59

In reply to Selegiline transdermal, why not phenelzine ?, posted by mattdds on February 2, 2004, at 12:42:06

> Does anyone know why they wouldn't explore an MAOI with a better track record (phenelzine, tranylcipromine, isocarboxazid) for transdermal delivery?
>
> There is likely a reason, perhaps that the other MAOI compounds cause dermatitis or something like that.
>
> Otherwise, I just couldn't imagine why a manufacturer would choose selegiline out of all the MAOI's, when it has the least supporting evidence for efficacy, especially with all those other wonderful MAOI's. Can you imagine transdermal Nardil, with no worries of food-induced hypertensive crises?
>
> Matt

because transdermal selegiline can be marketed for not only depression, but for ADD, and Parkinsons...plus Selegiline is a far superior med than Phenelzine (as far as side-effects, and toxicity) Selegiline has numerous other positive benefits (anti-oxidant, neuroprotection, etc)


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