Posted by Ilene on February 2, 2004, at 12:59:01
In reply to Selegiline transdermal, why not phenelzine ?, posted by mattdds on February 2, 2004, at 12:42:06
> Does anyone know why they wouldn't explore an MAOI with a better track record (phenelzine, tranylcipromine, isocarboxazid) for transdermal delivery?
>
> There is likely a reason, perhaps that the other MAOI compounds cause dermatitis or something like that.
>
> Otherwise, I just couldn't imagine why a manufacturer would choose selegiline out of all the MAOI's, when it has the least supporting evidence for efficacy, especially with all those other wonderful MAOI's. Can you imagine transdermal Nardil, with no worries of food-induced hypertensive crises?
>
> MattI'm with Chairman Mao on this--I think the potential market for a Parkinson's med is much larger than the market for a 3rd line AD. At the dose required for AD effect, I think people would still need to follow an MAOI diet.
Ilene
poster:Ilene
thread:308522
URL: http://www.dr-bob.org/babble/20040131/msgs/308532.html