Posted by djmmm on January 30, 2004, at 21:42:34
In reply to Re: NO! you need to taper and washout! » djmmm, posted by rod on January 30, 2004, at 4:25:27
> > > ..example: Effexor is a phenylalanine, as is the street drug Ecstacy...similar..but VERY different.
>
> Effexor is a phenylethylamine, not phenylalanine.
>
>
> > -- A wash out of 2 weeks is not necessary form Parnate to Nardil, a short washout is recomended when switching from Nardil to Parnate, but only because Nardil is an irreversible MAOI, and accumulates in the liver.
>
> You once wrote, that you can reduce nardil to 30mg because it accumulates in the liver. I dont understand this. Could you explain it to me?--sure thing, Phenelzine (Nardil) is a hydrazine deravitive, and hydrazine type drugs tend to accumulate (saturate) liver enzymes over time. If you take Nardil for an extended period of time, or at very high doses, you run the risk of hepatic injury (necrotizing hepatocellular damage)
Douesnt that mean there is also a drop in the blood level? Just because it accumulates in the liver isnt there just a longer time to reach a steady blood concentration?
-- When I suggested that you can decrease the dosage, this is independent of its concentration in whole blood...-- Nardil forms an irreversible covalent bond to monoamine oxidase (throughout the body), unlike Parnate (for example) you can decrease the dose because it takes a specific amount of time for your body to re-synthesize MAO...say for example, you were taking 60mg, and after 3 months, you felt nearly "recovered" You could then decrease the dosage to as little as 15mg 3x a week because of drug accumulation and the amount of time it takes your body (personally) to resynthesize MAO.
> thanks.
>
> Roland
>
>
>
poster:djmmm
thread:305978
URL: http://www.dr-bob.org/babble/20040127/msgs/307542.html