Posted by Chairman_MAO on January 29, 2004, at 21:01:21
In reply to Goodbye remeron--hello insomnia, posted by thinkfast on January 28, 2004, at 14:16:10
As joebob said, trazodone is good. Sedating tricyclics, such as doxepin and amitriptyline, are useful. The antipsychotic Seroquel is good for insomnia at dosages of 25-100mg 2 hours before sleep, though too high a dose and you might be groggy the next day for a few hours (not as long as remeron). Personally, I'd go with the anticonvulsant Gabitril (tiagabine) 2-12mg 1 hour before bedtime. When I took it I had fantastic sleep vivid dreams--and not the 5ht2a antagonist 'nightmare' types--with no groginess the next day. I've also given it to a few friends and they reported like results.
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The GABA uptake inhibitor tiagabine promotes slow wave sleep in normal elderly subjects.
Mathias S, Wetter TC, Steiger A, Lancel M.
Max Planck Institute of Psychiatry, Munich, Germany.
Aging is associated with a dramatic decrease in slow wave sleep (SWS) and sleep consolidation. Previous studies revealed that various GABA(A) agonists and the GABA uptake inhibitor tiagabine augment slow frequency components in the EEG within non-REM sleep, and thus promote deep sleep in young individuals and/or rats. In the present double-blind, placebo-controlled study, we assessed the effect of a single oral dose of 5 mg tiagabine on nocturnal sleep in ten healthy elderly volunteers (6 females). During the placebo night the subjects displayed a low sleep efficiency, due to high amounts of intermittent wakefulness, and little SWS. Tiagabine significantly increased sleep efficiency, tendentially decreased wakefulness and prominently increased both SWS and low-frequency activity in the EEG within non-REM sleep. The present findings demonstrate that tiagabine increases sleep quality in aged subjects. Moreover, the effects of tiagabine closely match those evoked by the GABA(A) agonist gaboxadol in young subjects and indicate that such compounds may have prospects in the treatment of sleep disturbances, particularly of those commonly occurring in the elderly.
poster:Chairman_MAO
thread:306495
URL: http://www.dr-bob.org/babble/20040127/msgs/307076.html