Posted by scott-d-o on January 21, 2004, at 4:35:36
In reply to Re: Dopamine system out of whack?, posted by epiphany on January 21, 2004, at 3:43:15
> Have you tried one of the newer antipsychotics taken at low dose? They sometimes help people with those symptoms of apathy, anhedonia. A lot of people here like Amisulpride. Zyprexa or Abilify can be good too if you are unable to obtain Amisulpride. I know they have an effect on dopamine, but I am not one to explain how or why. I'm sure you could find a lot of information about it on a search here.
>
> Here is a pubmed article on Amisulpride used for depression, just to give you an idea.
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12685917&dopt=Abstract
>
> Hope this helps
>Okay, I recently wrote a long post explaining the neurological difference between high and low dose amisulpride and it should apply to most antipsychotics as well. The post seemed to go unnoticed for the most part, so I will provide the link here:
http://www.dr-bob.org/babble/20040109/msgs/300303.html
Also, to the original poster who was complaining of the "ups and downs" of stimulants, I am wondering if you tried the extended-release formulations (Adderall XR, Concerta, etc.), or if you had only tried the immediate-release versions of stimulants?
I have dysthymic depression and have also been unresponsive to all the common antidepressants. Over the past two weeks I have trialed both Adderall and Ritalin and seemed to have a very positive response to Ritalin. The Adderall improved my focus, however, I still felt fatigued and unmotivated. I think this is because of amphetamines action at the dopamine transporter where it actually causes it to reverse its action and transport dopamine out of the presynaptic neuron, as opposed to Ritalin which just blocks the dopamine transporter altogether, preventing the reuptake of dopamine back into the neuron.
I plan to switch to the extended-release formulation of Ritalin, Concerta, starting next week. I also had a positive response to low-dose sulpiride, however it doesn't seem to work well in conjunction with a stimulant and seems to block much of their effects. I think I need the stimulant since I have comorbid inattentive ADD and the sulpiride just doesn't get it done in that area.
I am wondering if anyone who has had a positive response to Ritalin has tried Concerta and still could not deal with the come-downs?
scott
poster:scott-d-o
thread:303487
URL: http://www.dr-bob.org/babble/20040118/msgs/303594.html