Posted by temoigneur on December 3, 2003, at 1:40:33
In reply to Re: For Temo! » temoigneur, posted by ace on November 30, 2003, at 22:52:25
> > Hi Andrew, how are you, I feel bad always asking you questions, I'm always taking - thank you so much for reviewing my posts and giving such thoughtful suggestions, what you suggested at the end of the last post caught my attention.
>
> I'm on nardil and it definately kills my SP,GAD& PD, but does nothing for my crippling OCD.
>
> I'm so glad that Nardil helps with those problems- what dose are you on Ben?
>
On a relatively low dose of nardil, 30mg, I tried going up to ninety and brought on heavy>
depression.
>For my OCD my Pdoc has me on 7.5 mg zyprexa - to be honest this combination is about as good as anything I've been on except for a dramatic four month period when i first started prozac and felt wonderful - I loved school/socializing... However, the zyprexa leaves me sedated and dull.
>
> Zyprexa 2.5mg killed a part of my ocd- absolutely killed. But when I went higher than 2.5 it made my ocd worse!!
>
> Ouch, and you say it only killed part of your OCD, at any rate, If you respond to zyprexa like I have you haven't missed anything but feeling like you take a daily injection of concrete, but I'm sorry it made your OCD worse
>I wish so much there was something that could discriminately block the overactive dopamine receptors contributing to OCD without knocking me out, if dopamine is implicated as it it seems.
>
> Maybe you could give Amisulpride a try too- only minimal sedation so far.
>
> Ben- what about Clonidine? or Pindolol? or Lithium? Your OCD may be caused due to sluggish serotonergic transmission- Lithium and Pindolol would be great. Maybe, reboxetine- if its low Noradrenaline the prob- be careful combining with Nardil but.Sluggish Neurotransmission definately "feels" like part of the problem. In fact even when I was on this higher dose of zyprexa, there was one day where Inositol activated my mind and made me feel like I was at my prime. Sluggish neurotransmission, this may sound far fetched, folk-lore naivete, but in my desperation I went to a Chinese naturopath - who studied part way originally to become a medical doctor, and he told me my body fluids had condensed into a sort of mucus and it was causing poor neurotransmitter transduction.
Do you think lithium + pindolol could ameliorate this, did you mean to take them together? I've taken pindolol alone with nardil and lithium with an SSRI and neither of them helped, but is there some special mechanism by which the combination of the two could help with nardil/OCD? If I was to try this what dose range of the Lithium and Pindolol would seem reasonable, and when do you think a good time in the day would be to take them?
Unfortunately we don't have amisulpride in Canada.
I am getting a new doctor - an anxiety specialist on the 11th, so desperately hoping for insight there. BTW I happen to have Pindolol and Valproic acid, VA couldn't be substituted for lithium?, (shot in the dark)
>
> But you sound better than before which is great. Hows life going anyway- you back at school, got a job?I'm really hoping to be able to be in prime condition to go back to school in January, right now I'm just taking one course localy that I already took at the provincial university, as my
> mind just can't absorb much of anything on zyprexa, but I'm not in pain like I was beforeThank you so much ACE, I really appreciate your input.
Ben
poster:temoigneur
thread:284160
URL: http://www.dr-bob.org/babble/20031202/msgs/286118.html