Re: Celexa transport systems

Posted by Patient on October 11, 2003, at 16:37:42

In reply to Re: Celexa transport systems?, posted by Fuscia on August 5, 2002, at 13:09:14

> Hello pharmrep,
>
> Do you know what the transport system(s) is for citalopram? The following was posted by James Ferrell, but does not include information about citalopram.
>
> Thanks in advance for any information you can share! Fuscia
>
> Dr. Bob's Psychopharmacology Tips
> http://www.dr-bob.org/tips/
>
> "Date: Wed, 2 Apr 1997 15:05:51 -0800 (PST)
> From: ferrell@cmgm.stanford.edu (James Ferrell)
> Subject: Transport systems and antidepressants
>
> Here are some data to give you an idea of what transport systems are
> likely to be tweaked by the different antidepressants.
>
> From: Bolden-Watson C, Richelson E. Blockade by
> newly-developed antidepressants of biogenic amine uptake into rat
> brain synaptosomes. Life Sciences. 52 (12): 1023-9, 1993.
>
> ------------------------------------------------------
> Ki (nM)
> Drug ------------ Selectivity for 5HT
> ----------------5HT-----NE---(Ki NE / Ki 5HT)
> ------------------------------------------------------
> desipramine 180-------0.6-----0.003
> doxepin -----220------18------0.08
> amitriptyline -84------14------ 0.2
> imipramine ---41------14------0.3
>
> venlafaxine ---39-----210------5.4
>
> fluoxetine -----14-----143------10
> norfluoxetine --25----410------17
> paroxetine ------0.7----33------45
> sertraline -------3----220------64
> ------------------------------------------------------
>
> From: Hyttel J. Pharmacological characterization of selective
> serotonin reuptake inhibitors (SSRIs). International Clinical
> Psychopharmacology. 9 Suppl 1: 19-26, 1994 Mar.
>
> ------------------------------------
> Drug Selectivity for 5HT
> (IC50 NE / IC50 5HT)
> ------------------------------------
> clomiprimine 14
> fluoxetine 54
> fluvoxamine 160
> paroxetine 280
> sertraline 840
> ------------------------------------"
Well, I finally found , or rather, stumbled upon the answer to my question (formerly Fuscia). Thanks to D. Spinks* and G. Spinks at the Department of Medicinal Chemistry, Organon Laboratories Ltd., Newhouse, Lanarkshire, ML1 5SH, Scotland, UK
http://www.bentham.org/sample-issues/cmc9-8/spinks/table1.gif

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