Posted by Larry Hoover on September 5, 2003, at 7:52:14
In reply to Lar, Re:thyroid replacement , posted by tealady on September 2, 2003, at 22:52:47
> Lar,
> http://www.dr-bob.org/babble/20030828/msgs/255832.htmlFrom that post, I've brought forward some quotes, and I will reply here:
"The last blood test showed adding in tyrosine oo actually reduced my T4 and raised TSh. I had thought it would raise TSH, as the extra dopamine should do this..but I surprised my T4 dropped as well. I will keep trying"
Dopamine should reduce TSH, not raise it. The following document details the relationship comprehensively (see page 4).
http://www.thyroidmanager.org/Chapter4/4-text.htm
You also said:
"I have heard (but still no found the research on) that TSH kinda follows the cortisol circadian rhythm by maximizing at night..probably in early hours of morning. I KNOW TSH is higher in morning than in afternoon. I know that TSH stimulates production of T4(and T3)..so I guess this is maximized in the morning, and you would not need as much at night?..really no idea though.So if anyone knows anything about the daily cycle if thyroid hormone in our bodies could they please let me know,or point me to the source, thanks"
From the above document (page 3):
'TSH secretion in humans is pulsatile 220-223. The pulse frequency is slightly less than 2 hours and the amplitude approximately 0.6 mU/L. The TSH pulse is significantly synchronized with PRL pulse: this phenomenon is independent from TRH and suggests the existence of unidentified underlying pulse generator(s) for both hormones 224. The frequency and amplitude of pulsations increases during the evening reaching a peak at sleep onset, thus accounting for the circadian variation in basal serum TSH levels 225-227. The maximal serum TSH is reached between 21:00 and 02:00 hours and the difference between the afternoon nadir and peak TSH concentrations is 1 to 3 mU/L. Sleep prevents the further rise in TSH as reflected in the presence of increases in TSH to 5-10 mU/ml during sleep deprivation 228,229. The circadian variation of TSH secretion is probably the consequence of a varying dopaminergic tone modulating the pulsatile TSH stimulation by TRH229.1. There is little, if any, significant seasonal change in basal TSH nor are there any gender-related differences in either the amplitude or frequency of the TSH pulses 223. The diurnal rythmicity of serum TSH concentration is maintained in mild hyper- and hypothyroidism, but is abolished in severe short-term primary hypothyroidism, suggesting that the complete lack of negative feedback to the hypothalamus or pituitary or both may override the central influences on TSH secretion.229.2 '
> I found the Methocel info , if you are interested
> http://www.colorcon.com/pharma/mod_rel/methocel/literature/Hydroph_Matrix_Broch.pdf
>
> pp 13 of 37 ..graph..click on enlarge to 200% to see it!Thanks! This is an excellent application for methylcellulose polymers.
> All compounding pharmacies I have contacted so far all use METHOCEL E4M..which does look like the current optimal choice for the purpose.
>
> Note thought that with ONLY 25% Methocel, specified percentage of the drug you which to slow release and LACTOSE ..to speed up the release ..you get only about 80% of the drug (THYROID) in 8 1/2 hrs or so...90% in 12 hrs ..and 93% in 14 hrs etc.It would be virtually impossible to mimic the normal release of T4 with any oral drug regime. You'd have to have an implanted pump to come close. This drug carrier seems to be an excellent way to deliver thyroid hormone.
> Think I've got the drug release rate pretty right as I confirmed with my body temperatures, which are sensitive enough to the thyroid meds to act as a gauge
Way to go, for figuring that out. <grin>
> Really appreciate all your help,
>
> JanI'm glad to help. Let me know if I can help some more.
Lar
poster:Larry Hoover
thread:255272
URL: http://www.dr-bob.org/babble/20030902/msgs/257225.html